性高湖久久久久久久久,一色一伦一区二区三区,国产在线精品一区二区

您好，歡迎來到拜力生物網站！請登錄注冊

我的訂單 | 聯系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時間：08:30-17:30

主營產品： ELISA試劑盒、抗體、補體血清、兔補體、干擾素、小鼠測溫儀、進口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網站首頁產品中心代理品牌新聞資訊資源中心關于我們

所在位置：首頁 > 產品中心 > Xcessbio > Xcessbio產品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

OTX015,BETInhibitor

品牌：Xcessbio

貨號：60193-2s

規格：2 mg solid

貨期：

應用：

咨詢客服

立即購買加入購物車

OTX015,BETInhibitor

商品詳情參考文獻相關資料

Product Information

Molecular Weight:	491.99
Formula:	C₂₅H₂₂ClN₅O₂S
Purity:	≥98%
CAS#:	202590-98-5
Solubility:	DMSO up to 100 mM
Chemical Name:	(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

OTX015 is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC₅₀ of 10-19 nM. It inhibits the growth of a variety of human cancer cell lines with IC₅₀ ranging from 60 to 200 nM. OTX015 results in rapid down-regulation of c-MYC expression, and show the synergistic anti-proliferative effects in combination with ALK inhibitors in ALKpos ALCL cell lines. In vivo studies using OTX015 have demonstrated efficacy in a range of oncology models. OTX015 is currently in phase I clinical development for oncology indication.

How to Use:

In vitro: OTX015 was used at 2-10 μM final concentration in various in vitro assays.
In vivo: OTX015 could be dosed to the mice by oral administration at 100 mg/kg once per day or 10 mg/kg twice per day.

Reference:

1. Noel JK, et al. Development of the BET bromodomain inhibitor OTX015. (2013) Mol Cancer Ther. 12, C244.
2. Boi M, et al. OTX015, a bromodomain and extraterminal inhibitor, represents a novel agent for ALK positive anaplastic large cell lymphoma. (2013) Mol Cancer Ther. 12, A219.

Products are for research use only. Not for human use.

熱銷產品